Homogeneous Development of Electrical Heterogeneous Ion Channel Expression Excitabil ity via
نویسنده
چکیده
Synchronous differentiation of delayed-rectifier potassium curonly partially suppresses or has no effect on current. Thus, rent regulates electrical excitability and calcium entry in motor, diverse embryonic neurons coordinate differentiation of excitsensory, and interneurons of the developing amphibian spinal ability yet rely on heterogeneous potassium channel gene cord. Although Kvl and Kv2 potassium channel transcripts are expression. detectable in these cells, it is not known which transcript contributes to functional expression. Overexpression of a Kvl dominant-negative subunit indicates that 20% of neurons have
منابع مشابه
Electrical activity and calcium influx regulate ion channel development in embryonic Xenopus skeletal muscle.
The development of electrical excitability involves complex coordinated changes in ion channel activity. Part of this coordination appears to be due to the fact that the expression of some channels is dependent on electrical activity mediated by other channel types. For example, we have previously shown that normal potassium current development in embryonic skeletal muscle cells of the frog Xen...
متن کاملExpression and distribution of voltage-gated ion channels in ferret sinoatrial node.
Spontaneous diastolic depolarization in the sinoatrial (SA) node enables it to serve as pacemaker of the heart. The variable cell morphology within the SA node predicts that ion channel expression would be heterogeneous and different from that in the atrium. To evaluate ion channel heterogeneity within the SA node, we used fluorescent in situ hybridization to examine ion channel expression in t...
متن کاملA Comparative Study of the Effect of Homogeneous and Heterogeneous Collaborative Interaction on the Development of EFL Learners’ Writing Skill
This study investigates the effect of homogeneous and heterogeneous peer interaction on the development of Iranian EFL learners’ writing skill. Sixty female students of TEFL participated in the study. The participants were divided into two groups based on their English proficiency test scores. The homogeneous group consisted of 14 participants paired with partners with similar English proficien...
متن کاملFabrication of low cost in-house slab homogeneous and heterogeneous phantoms for lung radiation treatment
Background: The heterogeneous composition of the human body presents numerous tissue types and cavities with widely differing radiologic properties. The aim of the present work was to develop a low cost homogeneous and heterogeneous phantom and the absorbed dose were measured by ionization chamber for different radiotherapy treatment techniques and compared with treatment planning syst...
متن کاملGene Expression Profile of CatSper3 and CatSper4 during Postnatal Development of Mouse Testis
Channel activities, particularly those of calcium channels, have vital roles in the process of sperm maturation, motility and sperm-egg interaction. A group of the recently discovered ion channels associated with these processes is four novel channel-like proteins known as CatSper (cation channel sperm) gene family. CatSper1 and CatSper2 show sperm specific expression patterns. However, neither...
متن کامل